蛋白质组中心

科学研究

蛋白质组中心

陈涉博士

北京科学生命球友(中国)qy高级研究员，蛋白质组中心主任

Associate Investigator and Director of Proteomics Center, NIBS,Beijing, China

电话： 010-80726688-8370

E-mail: chenshe@xinjundu.com

中心主任介绍：

陈涉研究员1995年于武汉大学取得生物化学学士学位；1998年于中国科研实验室生物物理球友(中国)qy取得生物物理硕士学位；2000年于美国Iowa State University取得食品科学硕士学位；2009年于北京师范大学取得生物化学及分子生物学博士学位。2001年至2004年间分别于美国University of Texas Southwestern Medical Center at Dallas和美国MDS Proteomics Inc.公司从事蛋白质生物质谱技术工作。2004年回国建立北京科学生命球友(中国)qy蛋白质组中心并工作至今。2015年入选国家百千万人才工程，并取得国家有突出贡献中青年专家称号。现任北京科学生命球友(中国)qy高级研究员，蛋白组中心主任。

陈涉研究员致力于蛋白质生物质谱技术的开发和应用，将生物质谱技术运用到包括病原体和宿主的相互作用、程序性细胞死亡、真核生物细胞表观遗传学信息的传递、昼夜节律的调控等众多基础生物学领域，取得了一系列重要成果，并发表在包括Nature, Science, 球友(中国)qy在内的高水平国际期刊上。

北京科学生命球友(中国)qy蛋白质组中心简介:

北京科学生命球友(中国)qy蛋白质组中心筹建于2004年，中心的核心组成部分为生物质谱实验室，拥有Orbitrap Fusion Lumos、LTQ Orbitrap Velos、Q Exactive等多台大型生物质谱仪，为球友(中国)qy各实验室给予高质量的生物质谱分析服务。服务内容包括蛋白质和多肽分子量测定，蛋白质的鉴定，蛋白质翻译后修饰的分析与鉴定，复杂蛋白质混合样品的分析，以及蛋白质组的比较定量研究。

中心在持续开发和完善各种先进的生物质谱分析技术的基础上，致力于将这些技术有效的运用到基础生物学研究中去，帮助解决基础生物学研究领域中的各个重大生物学问题。中心广泛召开合作研究，根据各个具体生物学问题的需要开发和完善相应的生物质谱技术，加快这些生物学问题的解决，促进基础生物学研究领域的开展。

联系方式：

北京科学生命球友(中国)qy蛋白质组中心

电话：010-80726688转8372

传真：010-80727513

地址：北京市昌平区中关村科学生命园科学园路七号

邮编：102206

中心现有生物质谱仪:

Orbitrap Fusion Lumos质谱仪	Q Exactive质谱仪

LTQ Orbitrap Velos质谱仪

中心部分署名文章:

1. Zhao, Y., Lin, L., Wang, X., He, S., Shi, W., Chen, S. (2022). Temporal Proteomic and Phosphoproteomic Analysis of EV-A71-Infected Human 球友(中国)qys. J. Proteome Res.
(http://doi.org/10.1021/acs.jproteome.2c00237)

2. Li, D., Chen, J., Guo, J., Li, L., Cai, G., Chen, S., Huang, J., Yang, H., Zhuang, Y., Wang, F., and Wang, X. (2021). A phosphorylation of RIPK3 kinase initiates an intra球友(中国)qyular apoptotic pathway that promotes prostaglandin2alpha-induced corpus luteum regression. eLife 10: e67409

3. Lyu, X., Yang, Q., Li, L., Dang, Y., Zhou, Z., Chen, S., and Liu, Y. (2020). Adaptation of codon usage to tRNA I34 modification controls translation kinetics and proteome landscape. PLoS Genet. 16(6): e1008836

4. Yang, Z., Wang, C., Xue, Y., Liu, X., Chen, S., Song, C., Yang, Y., and Guo, Y. (2019). Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance. Nat. Commun. 10(1): 1199

5. Liu, J., Li, M., Li, L., Chen, S., and Wang, X. (2018). Ubiquitination of the PI3-kinase VPS-34 promotes VPS-34 stability and phagosome maturation. J. 球友(中国)qy Biol. 217(1): 347-360

6. Zhou, Y., Huang, C., Yin, L., Wan, M., Wang, X., Li, L., Liu, Y., Wang, Z., Fu, P., Zhang, N., Chen, S., Liu, X., Shao, F., and Zhu, Y. (2017). N(epsilon)-Fatty acylation of Rho GTPases by a MARTX toxin effector. Science 358(6362): 528-531

7. Zhang, L., Wu, C., Cai, G., Chen, S., and Ye, K. (2016). Stepwise and dynamic assembly of the earliest precursors of small ribosomal subunits in yeast. Genes Dev. 30(6): 718-732

8. Li, D., Xu, T., Cao, Y., Wang, H., Li, L., Chen, S., Wang, X., and Shen, Z. (2015). A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis. Proc. Natl. Acad. Sci. U. S. A. 112(16): 5017-5022

9. Guo, B., Liang, Q., Li, L., Hu, Z., Wu, F., Zhang, P., Ma, Y., Zhao, B., Kovacs, A.L., Zhang, Z., Feng, D., Chen, S., and Zhang, H. (2014). O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation. Nat. 球友(中国)qy Biol. 16(12): 1215-1226

10. Li, S., Zhang, L., Yao, Q., Li, L., Dong, N., Rong, J., Gao, W., Ding, X., Sun, L., Chen, X., Chen, S.^#, and Shao, F.^# (2013). Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains. Nature 501(7466): 242-246. ( ^#共同通讯作者).

11. Sun, L., Wang, H., Wang, Z., He, S., Chen, S., Liao, D., Wang, L., Yan, J., Liu, W., Lei, X., and Wang, X. (2012). Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase. 球友(中国)qy 148(1-2): 213-227

12. Xu, M., Wang, W., Chen, S.^#, and Zhu, B.^# (2012). A model for mitotic inheritance of histone lysine methylation. EMBO Rep. 13(1): 60-67. (^#共同通讯作者).

13. Zhang, L., Ding, X., Cui, J., Xu, H., Chen, J., Gong, Y. N., Hu, L., Zhou, Y., Ge, J., Lu, Q., Liu, L., Chen, S., and Shao, F. (2011). Cysteine methylation disrupts ubiquitin-chain sensing in NF-kappaB activation. Nature 481(7380): 204-208

14. Shang, L., Chen, S., Du, F., Li, S., Zhao, L., and Wang, X. (2011). Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK. Proc. Natl. Acad. Sci. U. S. A. 108(12): 4788-4793

15. Xu, M., Long, C., Chen, X., Huang, C., Chen, S.^#, and Zhu, B.^# (2010). Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly. Science 328(5974): 94-98. (^#共同通讯作者).

16. Cui, J., Yao, Q., Li, S., Ding, X., Lu, Q., Mao, H., Liu, L., Zheng, N., Chen, S., and Shao, F. (2010). Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science 329(5996): 1215-1218

17. Tang, C. T., Li, S., Long, C., Cha, J., Huang, G., Li, L., Chen, S.^#, and Liu, Y.^# (2009). Setting the pace of the Neurospora circadian clock by multiple independent FRQ phosphorylation events. Proc. Natl. Acad. Sci. U. S. A. 106(26): 10722-10727. (^#共同通讯作者).

18. Huang, G.*, Chen, S.*, Li, S., Cha, J., Long, C., Li, L., He, Q., and Liu, Y. (2007). Protein kinase A and casein kinases mediate sequential phosphorylation events in the circadian negative feedback loop. Genes Dev. 21(24): 3283-3295. (*共同第一作者).

中心全部署名文章:

1. Zhu, X., Yang, N., Yang, Y., Yuan, F., Yu, D., Zhang, Y., Shu, Z., Nan, N., Hu, H., Liu, X., Chen, S., Sun, L., and Wang, H. (2022). Spontaneous necroptosis and autoinflammation are blocked by an inhibitory phosphorylation on MLKL during neonatal development. 球友(中国)qy Res. 32(4): 407-410

2. Zhou, J.X., Su, X.M., Zheng, S.Y., Wu, C.J., Su, Y.N., Jiang, Z., Li, L., Chen, S., and He, X.J. (2022). The Arabidopsis NuA4 histone acetyltransferase complex is required for chlorophyll biosynthesis and photosynthesis. J. Integr. Plant Biol. 64(4): 901-914

3. Yan, B., Ding, Z., Zhang, W., Cai, G., Han, H., Ma, Y., Cao, Y., Wang, J., Chen, S., and Ai, Y. (2022). Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and 球友(中国)qy death. 球友(中国)qy Chem. Biol. 29(6): 958-969 e955

4. Qi, P.L., Zhou, H.R., Zhao, Q.Q., Feng, C., Ning, Y.Q., Su, Y.N., Cai, X.W., Yuan, D.Y., Zhang, Z.C., Su, X.M., Chen, S.S., Li, L., Chen, S., and He, X.J. (2022). Characterization of an autonomous pathway complex that promotes flowering in Arabidopsis. Nucleic Acids Res. 50(13): 7380-7395

5. Dou, C., Long, Z., Li, S., Zhou, D., Jin, Y., Zhang, L., Zhang, X., Zheng, Y., Li, L., Zhu, X., Liu, Z., He, S., Yan, W., Yang, L., Xiong, J., Fu, X., Qi, S., Ren, H., Chen, S., Dai, L., Wang, B., and Cheng, W. (2022). Crystal structure and catalytic mechanism of the MbnBC holoenzyme required for methanobactin biosynthesis. 球友(中国)qy Res. 32(3): 302-314

6. Wu, C.J., Liu, Z.Z., Wei, L., Zhou, J.X., Cai, X.W., Su, Y.N., Li, L., Chen, S., and He, X.J. (2021). Three functionally redundant plant-specific paralogs are core subunits of the SAGA histone acetyltransferase complex in Arabidopsis. Mol. Plant 14(7): 1071-1087

7. Tan, M., Li, S., Juillard, F., Chitas, R., Custodio, T.F., Xue, H., Szymula, A., Sun, Q., Liu, B., Alvarez, A.L., Chen, S., Huang, J., Simas, J.P., McVey, C.E., and Kaye, K.M. (2021). MLL1 is regulated by KSHV LANA and is important for virus latency. Nucleic Acids Res. 49(22): 12895-12911

8. Shang, J.Y., Lu, Y.J., Cai, X.W., Su, Y.N., Feng, C., Li, L., Chen, S., and He, X.J. (2021). COMPASS functions as a module of the INO80 chromatin remodeling complex to mediate histone H3K4 methylation in Arabidopsis. Plant 球友(中国)qy 33(10): 3250-3271

9. Qian, F., Zhao, Q.Y., Zhang, T.N., Li, Y.L., Su, Y.N., Li, L., Sui, J.H., Chen, S., and He, X.J. (2021). A histone H3K27me3 reader cooperates with a family of PHD finger-containing proteins to regulate flowering time in Arabidopsis. J. Integr. Plant Biol. 63(4): 787-802

10. Liu, S., Liu, S., He, B., Li, L., Li, L., Wang, J., Cai, T., Chen, S., and Jiang, H. (2021). OXPHOS deficiency activates global adaptation pathways to maintain mitochondrial membrane potential. EMBO reports 22(4): e51606

11. Li, D., Chen, J., Guo, J., Li, L., Cai, G., Chen, S., Huang, J., Yang, H., Zhuang, Y., Wang, F., and Wang, X. (2021). A phosphorylation of RIPK3 kinase initiates an intra球友(中国)qyular apoptotic pathway that promotes prostaglandin2alpha-induced corpus luteum regression. eLife 10: e67409

12. Hu, X., Li, Y., Zhang, T., Li, L., Chen, S., Wu, X., Li, H., Qi, B., and Chen, Z. (2021). Phosphorylation of Ago2 is required for its role in DNA double-strand break repair. J Genet. Genomics 48(4): 333-340

13. Guo, J., Wei, L., Chen, S.S., Cai, X.W., Su, Y.N., Li, L., Chen, S., and He, X.J. (2021). The CBP/p300 histone acetyltransferases function as plant-specific MEDIATOR subunits in Arabidopsis. J. Integr. Plant Biol. 63(4): 755-771

14. Feng, C., Cai, X.W., Su, Y.N., Li, L., Chen, S., and He, X.J. (2021). Arabidopsis RPD3-like histone deacetylases form multiple complexes involved in stress response. J. Genet. Genomics 48(5): 369-383

15. Ao, K., Tong, M., Li, L., Ludke, D., Lipka, V., Chen, S., Wiermer, M., and Li, X. (2021). SCF(SNIPER7) controls protein turnover of unfoldase CDC48A to promote plant immunity. New Phytol. 229(5): 2795-2811

16. Zhou, S., Zhang, W., Cai, G., Ding, Y., Wei, C., Li, S., Yang, Y., Qin, J., Liu, D., Zhang, H., Shao, X., Wang, J., Wang, H., Yang, W., Wang, H., Chen, S., Hu, P., and Sun, L. (2020). Myofiber necroptosis promotes muscle stem 球友(中国)qy proliferation via releasing Tenascin-C during regeneration. 球友(中国)qy Res. 30(12): 1063-1077

17. Zhou, H.R., Lin, R.N., Huang, H.W., Li, L., Cai, T., Zhu, J.K., Chen, S., and He, X.J. (2020). The CCR4-NOT complex component NOT1 regulates RNA-directed DNA methylation and transcriptional silencing by facilitating Pol IV-dependent siRNA production. Plant J. 103(4): 1503-1515

18. Tan, L.M., Liu, R., Gu, B.W., Zhang, C.J., Luo, J., Guo, J., Wang, Y., Chen, L., Du, X., Li, S., Shao, C.R., Su, Y.N., Cai, X.W., Lin, R.N., Li, L., Chen, S., Du, J., and He, X.J. (2020). Dual Recognition of H3K4me3 and DNA by the ISWI Component ARID5 Regulates the Floral Transition in Arabidopsis. Plant 球友(中国)qy 32(7): 2178-2195

19. Ning, Y.Q., Liu, N., Lan, K.K., Su, Y.N., Li, L., Chen, S., and He, X.J. (2020). DREAM complex suppresses DNA methylation maintenance genes and precludes DNA hypermethylation. Nat. Plants 6(8): 942-956

20. Lyu, X., Yang, Q., Li, L., Dang, Y., Zhou, Z., Chen, S., and Liu, Y. (2020). Adaptation of codon usage to tRNA I34 modification controls translation kinetics and proteome landscape. PLoS Genet. 16(6): e1008836

21. Luo, Y.X., Hou, X.M., Zhang, C.J., Tan, L.M., Shao, C.R., Lin, R.N., Su, Y.N., Cai, X.W., Li, L., Chen, S., and He, X.J. (2020). A plant-specific SWR1 chromatin-remodeling complex couples histone H2A.Z deposition with nucleosome sliding. EMBO J. 39(7): e102008

22. Li, D., Ai, Y., Guo, J., Dong, B., Li, L., Cai, G., Chen, S., Xu, D., Wang, F., and Wang, X. (2020). Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3. eLife 9: e61564

23. Ju, D., Zhang, W., Yan, J., Zhao, H., Li, W., Wang, J., Liao, M., Xu, Z., Wang, Z., Zhou, G., Mei, L., Hou, N., Ying, S., Cai, T., Chen, S., Xie, X., Lai, L., Tang, C., Park, N., Takahashi, J.S., Huang, N., Qi, X., and Zhang, E.E. (2020). Chemical perturbations reveal that RUVBL2 regulates the circadian phase in mammals. Sci. Transl. Med. 12(542)

24. Johnston, A.N., Ma, Y., Liu, H., Liu, S., Hanna-Addams, S., Chen, S., Chen, C., and Wang, Z. (2020). Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis. Proc. Natl. Acad. Sci. U. S. A. 117(12): 6521-6530

25. Jiang, Z., Jin, X., Li, Y., Liu, S., Liu, X.M., Wang, Y.Y., Zhao, P., Cai, X., Liu, Y., Tang, Y., Sun, X., Liu, Y., Hu, Y., Li, M., Cai, G., Qi, X., Chen, S., Du, L.L., and He, W. (2020). Genetically encoded tags for direct synthesis of EM-visible gold nanoparticles in 球友(中国)qys. Nat. Methods 17(9): 937-946

26. Jiang, X., Wang, X., Ding, X., Du, M., Li, B., Weng, X., Zhang, J., Li, L., Tian, R., Zhu, Q., Chen, S., Wang, L., Liu, W., Fang, L., Neculai, D., and Sun, Q. (2020). FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER-phagy. EMBO J. 39(5): e102608

27. Hanna-Addams, S., Liu, S., Liu, H., Chen, S., and Wang, Z. (2020). CK1alpha, CK1delta, and CK1epsilon are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosis. Proc. Natl. Acad. Sci. U. S. A. 117(4): 1962-1970

28. Gu, B.W., Tan, L.M., Zhang, C.J., Hou, X.M., Cai, X.W., Chen, S., and He, X.J. (2020). FHA2 is a plant-specific ISWI subunit responsible for stamen development and plant fertility. J. Integr. Plant Biol. 62(11): 1703-1716

29. Gao, L., Su, C., Du, X., Wang, R., Chen, S., Zhou, Y., Liu, C., Liu, X., Tian, R., Zhang, L., Xie, K., Chen, S., Guo, Q., Guo, L., Hano, Y., Shimazaki, M., Minami, A., Oikawa, H., Huang, N., Houk, K.N., Huang, L., Dai, J., and Lei, X. (2020). FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis. Nat. Chem. 12(7): 620-628

30. Zhu, W., Li, J., Zhang, R., Cai, Y., Wang, C., Qi, S., Chen, S., Liang, X., Qi, N., and Hou, F. (2019). TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity. EMBO J. 38(18): e102075

31. Zhao, Q.Q., Lin, R.N., Li, L., Chen, S., and He, X.J. (2019). A methylated-DNA-binding complex required for plant development mediates transcriptional activation of promoter methylated genes. J. Integr. Plant Biol. 61(2): 120-139

32. Yang, Z., Wang, C., Xue, Y., Liu, X., Chen, S., Song, C., Yang, Y., and Guo, Y. (2019). Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance. Nat. Commun. 10(1): 1199

33. Ning, Y.Q., Chen, Q., Lin, R.N., Li, Y.Q., Li, L., Chen, S., and He, X.J. (2019). The HDA19 histone deacetylase complex is involved in the regulation of flowering time in a photoperiod-dependent manner. Plant J. 98(3): 448-464

34. Li, D., Chen, J., Ai, Y., Gu, X., Li, L., Che, D., Jiang, Z., Li, L., Chen, S., Huang, H., Wang, J., Cai, T., Cao, Y., Qi, X., and Wang, X. (2019). Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover. Mol. 球友(中国)qy 75(6): 1103-1116 e1109

35. Fan, W., Guo, J., Gao, B., Zhang, W., Ling, L., Xu, T., Pan, C., Li, L., Chen, S., Wang, H., Zhang, J., and Wang, X. (2019). Flotillin-mediated endocytosis and ALIX-syntenin-1-mediated exocytosis protect the 球友(中国)qy membrane from damage caused by necroptosis. Sci. Signal. 12(583)

36. Ding, X., Jiang, X., Tian, R., Zhao, P., Li, L., Wang, X., Chen, S., Zhu, Y., Mei, M., Bao, S., Liu, W., Tang, Z., and Sun, Q. (2019). RAB2 regulates the formation of autophagosome and autolysosome in mammalian 球友(中国)qys. Autophagy 15(10): 1774-1786

37. Cheng, X., Ma, X., Zhu, Q., Song, D., Ding, X., Li, L., Jiang, X., Wang, X., Tian, R., Su, H., Shen, Z., Chen, S., Liu, T., Gong, W., Liu, W., and Sun, Q. (2019). Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism. Mol. 球友(中国)qy 73(4): 788-802 e787

38. Zhou, J.X., Liu, Z.W., Li, Y.Q., Li, L., Wang, B., Chen, S., and He, X.J. (2018). Arabidopsis PWWP domain proteins mediate H3K27 trimethylation on FLC and regulate flowering time. J. Integr. Plant Biol. 60(5): 362-368

39. Ying, Z., Pan, C., Shao, T., Liu, L., Li, L., Guo, D., Zhang, S., Yuan, T., Cao, R., Jiang, Z., Chen, S., Wang, F., and Wang, X. (2018). Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury. Mol. 球友(中国)qy 72(3): 457-468 e455

40. Wang, J., Grubb, L.E., Wang, J., Liang, X., Li, L., Gao, C., Ma, M., Feng, F., Li, M., Li, L., Zhang, X., Yu, F., Xie, Q., Chen, S., Zipfel, C., Monaghan, J., and Zhou, J.M. (2018). A Regulatory Module Controlling Homeostasis of a Plant Immune Kinase. Mol. 球友(中国)qy 69(3): 493-504 e496

41. Tan, L.M., Zhang, C.J., Hou, X.M., Shao, C.R., Lu, Y.J., Zhou, J.X., Li, Y.Q., Li, L., Chen, S., and He, X.J. (2018). The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing. EMBO J. 37(19)

42. Qin, J., Wang, K., Sun, L., Xing, H., Wang, S., Li, L., Chen, S., Guo, H.S., and Zhang, J. (2018). The plant-specific transcription factors CBP60g and SARD1 are targeted by a Verticillium secretory protein VdSCP41 to modulate immunity. eLife 7: e34902

43. Qi, C., Wang, X., Shen, Z., Chen, S., Yu, H., Williams, N., and Wang, G. (2018). Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer 球友(中国)qys. 球友(中国)qy Res. 28(5): 544-555

44. Luo, Y.X., Han, Y.F., Zhao, Q.Y., Du, J.L., Dou, K., Li, L., Chen, S., and He, X.J. (2018). Sumoylation of SUVR2 contributes to its role in transcriptional gene silencing. Science China. Life sciences 61(2): 235-243

45. Liu, W., Zhou, Y., Peng, T., Zhou, P., Ding, X., Li, Z., Zhong, H., Xu, Y., Chen, S., Hang, H.C., and Shao, F. (2018). N(epsilon)-fatty acylation of multiple membrane-associated proteins by Shigella IcsB effector to modulate host function. Nat. Microbiol. 3(9): 996-1009

46. Liu, J., Li, M., Li, L., Chen, S., and Wang, X. (2018). Ubiquitination of the PI3-kinase VPS-34 promotes VPS-34 stability and phagosome maturation. J. 球友(中国)qy Biol. 217(1): 347-360

47. Liang, X., Ma, M., Zhou, Z., Wang, J., Yang, X., Rao, S., Bi, G., Li, L., Zhang, X., Chai, J., Chen, S., and Zhou, J.M. (2018). Ligand-triggered de-repression of Arabidopsis heterotrimeric G proteins coupled to immune receptor kinases. 球友(中国)qy Res. 28(5): 529-543

48. Dong, O.X., Ao, K., Xu, F., Johnson, K.C.M., Wu, Y., Li, L., Xia, S., Liu, Y., Huang, Y., Rodriguez, E., Chen, X., Chen, S., Zhang, Y., Petersen, M., and Li, X. (2018). Individual components of paired typical NLR immune receptors are regulated by distinct E3 ligases. Nat. Plants 4(9): 699-710

49. Bi, G., Zhou, Z., Wang, W., Li, L., Rao, S., Wu, Y., Zhang, X., Menke, F.L.H., Chen, S., and Zhou, J.M. (2018). Receptor-Like Cytoplasmic Kinases Directly Link Diverse Pattern Recognition Receptors to the Activation of Mitogen-Activated Protein Kinase Cascades in Arabidopsis. Plant 球友(中国)qy 30(7): 1543-1561

50. Aharoni-Kats, L., Zelinger, E., Chen, S., and Yarden, O. (2018). Altering Neurospora crassa MOB2A exposes its functions in development and affects its interaction with the NDR kinase COT1. Mol. Microbiol. 108(6): 641-660

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